The AFFINImeter innovation team has developed an original model to analyze dissociation ITC isotherms of aggregates ranging from (protein) dimers to large supramolecular clusters (like micelles). With this model the average number of molecules in the aggregates, the molar free energy and enthalpy of transfer from the aggregate to the solution and the dilution of both monomers and aggregates can be obtained. This model soon will be available in the AFFINImeter Software.
The validation of this model comparing our results with those determined from other experimental methods is going to be presented in the 20th International Symposium on Surfactants in Solution (SIS, June 2014), where our CSO Angel Piñeiro is giving Oral presentation on Monday June 23, 2014.